Table 3.
Pharmacokinetics parameters of BPF
| Male | Female | ||||
|---|---|---|---|---|---|
| AUC0-72 h | (ng·h/ml) | 15112.95 ± 4854.7 | (5) | 23377.32 ± 4478.28 | (5) |
| Cmax | (ng/ml) | 12552.67 ± 3468.59 | (5) | 16101.55 ± 4016.43 | (5) |
| Tmax | (h) | 0.25 ± 0.00 | (5) | 0.25 ± 0.00 | (5) |
| Vd | (ng/kg) | 194639.26 ± 101617.42 | (5) | 216032.65 ± 76471.91 | (5) |
| T1/2 | (h) | 9.02 ± 2.69 | (5) | 21.77 ± 3.96 | (5) |
| Cl | (ml/h/kg) | 14642.2 ± 5763.66 | (5) | 9581.73 ± 1294.14 | (5) |
AUC Area under the curve, Cmax the peak plasma concentration of a drug after administration, Tmax time to reach Cmax, Vd volume of distribution, T1/2 absorption half-life, Cl clearance
200 mg/ml of BPF was treated in male and female SD rats. N = 5