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. 2021 Dec 11;61(5):655–672. doi: 10.1007/s40262-021-01070-6

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/.

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Fig. 1 — Observed maximum (top panel) and minimum (bottom panel) meropenem concentrations in plasma (total) and in the interstitial space fluid of subcutaneous adipose tissue obtained via microdialysis (unbound) using two catheters for obese (red, n = 15) and non-obese (green, n = 15) patients. Boxplots show the second to third quartile (box) and observations within (whiskers) and outside (dots) the interquartile range. Dashed horizontal lines indicate the minimum inhibitory concentrations. ISF interstitial space fluid, s.c. subcutaneous