Table 2.

Frequencies of adverse side effects in 226 hospitalized patients treated for a clinical diagnosis of major depressive disorders (ICD10 F3)

Percentage of F3 patients reporting adverse side effects
	Day_01 (%)	Day_10 (%)	Severe forms (%)
Neurological disturbances	41.31	39.96	9.31
Sexuality	49.10	50.78	41.45
Cardiac-respiratory disturbances	50.41	49.03	25.44
Autonomic disturbances	54.90	55.17	26.00
Appetite increased/decreased	56.34	56.73	35.10
Psychosomatic disturbances	61.52	60.33	30.90
Gastrointestinal disturbances	67.17	66.37	26.34
Cardiovascular disturbances	71.31	72.32	36.41
Sleep	79.38	78.95	56.83

Adverse side effects were assessed by a specifically trained health professional on the basis of a catalog of 46 items covering 9 adverse side effect clusters (first column). The severity of an adverse reaction was rated as mild, moderate, severe, and very severe. The nine clusters are sorted in ascending order of frequency from 41.31% (neurological disturbances) to 79.38% (sleep). Percentages relate to the first 3 days of treatment (Day_01) and to the 10th day of treatment (Day_10), displaying only minor changes over time. The percentages of severe forms (rated as severe or very severe) are given in the last column