Fig. 4. Transferability of previous lipid-trait associations to various African GWASs.
a LDL-C association signals detected in the Global Lipid Genetics Consortium (GLGC)15 study. b LDL-C association signals detected in Population Architecture using Genomics and Epidemiology Consortium (PAGE)36 study. The Y-axis shows the proportion of associated loci that are replicated in each of the individual African studies. The proportion of signals replicated at the genome-wide significance threshold P-value < 5 × 10−8 are shown in deep blue (F-GW), at P-value < 5 × 10−4 are shown in dark green (F_RepThr) and at the nominal threshold of P-value < 0.05 are shown in orange (F_NT). The signals from the GLGC study were partitioned on the basis of signal strength into Very Strong (P-value < 10−100) indicated by the suffix “_VS” and a green background, Strong (10−20 > P-value > 10−100) indicated by the suffix “_S” and a blue background, and moderate (5 × 10−8 > P-value > 10−20) indicated by the suffix “_M” and a grey background. For the PAGE study only two categories, Strong (S) (P-value < 10−20) and Moderate (M) (5 × 10−8 > P-value > 10−20) were considered. The African replication datasets used in the analysis are – Stage 2 GWAS (Meta-analysis) (N = 23,718), Stage 1 GWAS (AWI-Gen) (N = 10,603), Uganda Genome Resource (UGR) study (N = 6407), Africa-America Diabetes Mellitus (AADM) study (N = 4116), Durban Diabetes study (DDS) (N = 1117) and Durban case control (DCC) study (N = 1475). Comparison of transferability of signals from c GLGC Consortium study, d PAGE Consortium study in the Stage 2 GWAS results for each of the four lipid traits are shown.