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. 2022 May 11;13:2576. doi: 10.1038/s41467-022-30216-8

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Representative real-time cell analysis (RTCA) data showing NK cell cytotoxicity against A549-spike or parental A549 cells at an effector (E)/target (T) ratio of 1:4. b RTCA data showing NK cell cytotoxicity against A549-spike or parental A549 cells at an E/T ratio of 1:8. c Data from the RTCA assay analyzed at three different E/T ratios are summarized for cells from 6 donors. P values were determined with one-way ANOVA with multiple comparisons and adjusted by the Hochberg method. Data are presented as mean ± SEM. d Expression of CD107a, TNF-α, and IFN-γ was measured on transduced NK cells co-cultured with A549-spike or parental A549 cells for 4 h at an E/T ratio of 4:1. Data are summarized for NK cells from 7 donors. P values were determined by one-way ANOVA with multiple comparisons and adjusted by the Holm-Sidak or Dunn’s method. Data are presented as mean ± SD. e IL-15 production by ex vivo-expanded control tEGFR NK cells or mACE2-CAR_sIL15 NK cells cultured in the presence or absence of A549-spike cells for 72 h. Data are summarized for NK cells from four donors. P values were determined by one-way ANOVA with multiple comparisons and adjusted by the Holm–Sidak method. Data are presented as mean ± SD. Source data are provided as a Source Data file.