Table 1.

Checklist for artifact mitigation of aDBS system with concurrent sensing and stimulation.

	Signal chain element	Mitigation strategy and potential trade-offs (vs)
1	IPG location to reduce ECG artifact	Right chest, cranial, use of active recharge stimulation vs power consumption
2	DBS electrode impedance	Minimize tissue electrode impedance mismatch, symmetric dipole arrangement
3	Frontend sensing	Leakage current, polarization management, use of active recharge stimulation, stimulation pulse ‘sense blanking’
4	Digital signal processing	Time vs frequency resolution trade-off in classifier, dynamic range management vs resolution floor
5	Adaptive DBS algorithm	Clock synchronization and ‘algorithm blanking’ (post-stim lockout period)
6	Stimulation modulation	Stimulation ramps and stimulation amplitude transitions vs response time and dynamic range of adaptive stimulation algorithm