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. 2022 May 11;13(5):449. doi: 10.1038/s41419-022-04866-x

Fig. 6. ER mimetics modulates OGD/R-induced microglial activation and angiogenesis partially via SIRT6.

Fig. 6

shNC or shSIRT6 lentivirus-infected HAPI cells and BMVECs were pre-treated with vehicle control, metformin or resveratrol for 12 h, followed by OGD/R treatment. A The mRNA levels of cytokines in HAPI cells were determined by qRT-PCR. B The protein levels of target proteins in HAPI cells were determined by Western blotting. C The cell viability of BMVECs was monitored by MTT assays. D The angiogenesis of BMVECs was evaluated by tube formation assay. E The protein levels of target proteins in BMVECs were determined by Western blotting. β-actin acted as a loading control for Western blotting. *p < 0.05, **p < 0.01, and ***p < 0.001.