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. 2022 May 11;13:2606. doi: 10.1038/s41467-022-30070-8

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Pairwise cosine similarity (in red) among the average embeddings of 20,000 randomly selected sequences from each environmental package. b t-SNE visualization of the embedding space for 20,000 randomly selected sequences from each of ten distinct environmental contexts in the “mi-faser functional” validation set. Sequences from the same environmental context generally cluster together. Colors indicate environmental package. Embeddings are significantly differentiated by environmental package (MANOVA P < 10⁻¹⁶). Source data are provided as a Source Data file.