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. Author manuscript; available in PMC: 2022 Dec 15.
Published in final edited form as: J Immunol. 2021 Nov 12;207(12):3122–3130. doi: 10.4049/jimmunol.2001152

Figure 2. Obesity alters tumor immune cell landscape.

Figure 2.

A. UMAP plot with SingleR desgnations from single-cell RNA sequencing of CD45+ sorted intratumoral cells from lean and obese mice with subcutaneous MC38 tumors (3 tumors from each diet were pooled together in equal number of live cells). B. Density Gradient UMAP plots for LFD and HFD intratumoral cells. C. Frequency of singleR designated immune cell subtypes within respective diet. D. Violin Plots of Single cell gene expression of CD8+ T Cells and macrophages from CD45+ intratumoral cells in LFD and HFD treatments. Lack of statistical significance is indicated by “ns” while the other plots were at least p<0.05 significant following corrections.