Table 1.

PICOS criteria

Population	Patients (anµy age) with VSP-related complications following aSAH after clipping surgery or coiling
Interventions/comparators	Any treatment received in ICU and post-ICU setting or no intervention (for economic and humanistic burden)
Outcomes - Economic	During or post-hospitalization:
	Direct costs
	Indirect costs
	Economic model results (e.g., ICER, LYG, cost per QALY)
	Hospitalization journey (e.g., length of stay)
	Resource use
Outcomes - Humanistic	Utility, disutility scores
	Health-related quality of life measures (e.g., SF-36, EQ5D)
	Loss of productivity
	Caregiver burden
Study design	Clinical trials (RCTs, NRS)
	Observational studies (any study design); real-world studies, hospital databases or chart reviews, economic or cost/utility studies (CEA, CUA, BIA, CMA), studies reporting on humanistic outcomes
	Excluded: commentaries, expert reviews, case reports
Other considerations	Studies of aSAH survivors with subset of VSP patients to be included
	Minimum sample size: ≥ 2 individuals
Exclusion criteria	Studies not meeting the inclusion criteria outlined above

aSAH, aneurysmal subarachnoid hemorrhage; BIA, budget impact analysis; CEA, cost-effectiveness analysis; CMA, cost-minimization analysis; CUA, cost-utility analysis; EQ-5D, EuroQoL 5-Dimensions; ICER, incremental cost-effectiveness ratio; ICU, intensive care unit; LYG, life-years gained; NRS, nonrandomized study; QALY, quality-adjusted life years; RCT, randomized controlled trial; SF-36, 36-item Short-Form Health Survey; VSP, vasospasm