Table 2.
Length of hospital stay (days) by VSP status
| Author (date) Study ID |
Data collection | Treatment | Population | Total | ICU | |||
|---|---|---|---|---|---|---|---|---|
| Mean (SD) | Median | Mean (SD) | Median | |||||
| Clinical trials | ||||||||
|
Macdonald et al. (2012) [27] CONSCIOUS-1 |
2005–2006 | Clazosentan | Severe aVSP | 24.5 (–)* | – | 17α* | – | |
| No aVSP | 19.8 (–) | – | 11α | – | ||||
|
Rivero-Arias et al. (2009) [32] ISAT^ |
1997–2002 | Coiling/neurosurgical treatment | DCI, during first episode | 38.7 (56.4)* | – | 7.0 (5.7)* | – | |
| No DCI, during first episode | 23.6 (44.0) | – | 4.9 (5.9) | – | ||||
| Coiling/neurosurgical treatment | DCI, during subsequent episodes | – | – | 13 (0)* | – | |||
| No DCI, during subsequent episodes | – | – | 3.5 (4.9) | – | ||||
| Prevedello et al. (2006) [29] | 2000–2004 | HHH therapy + nimodipine | VSP | 32.1 (22.1)* | – | – | – | |
| No VSP | 15.1 (12.7) | – | – | – | ||||
| Magnesium sulfate | VSP | 19.4 (6.9) | – | – | – | |||
| No VSP | 19 (8.5) | – | – | – | ||||
| Observational studies | ||||||||
| Chotai et al. (2021) [42] | 2012–2015 | Mixed (coiling, clipping) | VSP | – | 20 (IQR: 15–26)* | – | – | |
| No VSP | – | 15 (IQR: 10–22) | – | – | ||||
| Abulhasan et al. (2018) [35] | 2010–2016 | Unspecified | VSP with DCI | – | * | – | * | |
| Alaraj et al. (2017) [36] | 2011–2014 | Mixed (coiling, clipping) | VSP | 24.1 (–)* | – | – | – | |
| No VSP | 15.9 (–) | – | – | – | ||||
| Drazin et al. (2015) [44] | – | Mixed (coiling, clipping) | VSP (clinical, with neurological deterioration) | – | – | * | – | |
| Chou et al. (2010) [43] | 1999–2004 | Mixed (coiling, clipping) | TCD-defined VSP | 21.3 (9.8)** | 18.5 (range: 5–54) | – | – | |
| No TCD-defined VSP | 16.6 (8.3) | 15 (range: 4–49) | – | – | ||||
| Mixed (coiling, clipping) | DCI | 23.5 (9)** | 22 (range: 10–50) | – | – | |||
| No DCI | 17.5 (9.1) | 15 (range: 4–54) | – | – | ||||
| Frontera et al. (2009) [11] | 1996–2002 | Unspecified | VSP | *† | – | *† | – | |
| Badjatia et al. (2005) [39] | 1995–2002 | Mixed (coiling, clipping) | Symptomatic VSP | 26 (13.8)* | – | 16.9 (7.9)* | – | |
| No aVSP | 20.2 (10.6) | – | 12.3 (5.7) | – | ||||
| Yundt et al. (1996) [64] | 1993–1994 | Mixed (clipping, not specified) | VSP | 28.4 (13.8) (nr) | – | 18.5 (9.7) (nr) | – | |
| No VSP | 17.0 (15.0) | – | 11.1 (11.3) | – | ||||
aSAH, aneurysmal subarachnoid hemorrhage; aVSP, angiographic vasospasm; DCI, delayed cerebral infarction; HHH, hypertension, hypervolemia, and hemodilution; IQR, interquartile range; SAH, subarachnoid hemorrhage; SD, standard deviation; TCD, transcranial Doppler; VSP, cerebral vasospasm
*p < 0.001; **p < 0.05; nr, p-value not reported. ^All data presented in the post hoc ISAT analysis refer to mean resource use per patient (SD). αFigures are taken as approximations from the graphs in the publication. †Significantly longer for VSP subgroup, but exact numbers not reported and only available in a 3D graph which does not allow for approximation of results