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. 2022 Apr 28;10:861327. doi: 10.3389/fcell.2022.861327

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Copyright © 2022 Huang, Yao, Ye, Huang, Zhang, Jiang and Xi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Gender differences in renal ischemia-reperfusion injury. (A,B) Serum creatinine levels (A) and serum urea nitrogen levels (B) of male and female mice in renal ischemia for 45 min and 24 h after reperfusion. (C) HE staining of renal tissue (original magnification ×200). Renal tubule injury is characterized by renal tubular atrophy and dilation, accompanied by tubular type. (D) Corresponding renal tissue pathological damage score. (E) Representative photograph for TUNEL staining section of renal tubular epithelial cells (green) in each group. Original magnification: ×400. Scale bar: 20 µm. (F) Quantitative evaluation of TUNEL-positive cells in renal tissue. The data displayed are mean ± SEM (n > 5). Compared with sham operation group, *p < 0.05. Compared with female renal IR group, #p < 0.05.