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. 2022 Apr 28;10:861327. doi: 10.3389/fcell.2022.861327

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Copyright © 2022 Huang, Yao, Ye, Huang, Zhang, Jiang and Xi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Silencing AR expression aggravates renal ischemia-reperfusion injury in male mice. (A,B) Effects of AR-shRNA silencing AR expression on the level of serum creatinine (A) and serum urea nitrogen (B) in male mice. (C) HE staining of renal tissue in each group (original magnification ×200). (D) Corresponding renal tissue pathological damage score. (E) Representative photograph for TUNEL staining section of renal tubular epithelial cells (green) in each group. Original magnification: ×400. Scale bar: 20 µm. (F) Quantitative evaluation of TUNEL-positive cells in renal tissue. Data displayed are mean ± SEM (n > 5). Compared with sham operation group, *p < 0.05. Compared with Control + IR group, #p < 0.05.