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. 2022 Apr 28;10:861327. doi: 10.3389/fcell.2022.861327

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Copyright © 2022 Huang, Yao, Ye, Huang, Zhang, Jiang and Xi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of silencing AR expression on miR-21 level and renal tubular cell apoptosis. (A) qPCR showing knocking down AR decreased AR mRNA level after renal ischemia-reperfusion injury in male mice. (B) Silencing AR decreased miR-21 level after renal ischemia-reperfusion injury. (C) Silencing AR increased PDCD4 mRNA level renal after ischemia-reperfusion injury. (D) Western blot showing knocking down AR increased cleaved caspase-3 and PDCD4 protein levels in renal tissue after renal ischemia-reperfusion. (E) Quantitative evaluation of PDCD4 protein levels in renal tissue. (F) Quantitative evaluation of cleaved caspase-3 protein levels in renal tissue. Data presented are mean ± SEM (n > 5). Compared with sham operation group, *p < 0.05. Compared with Control + IR group, #p < 0.05.