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. 2022 Apr 28;10:861327. doi: 10.3389/fcell.2022.861327

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Copyright © 2022 Huang, Yao, Ye, Huang, Zhang, Jiang and Xi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MiR-21 reduces renal tubular cell apoptosis by targeting PDCD4 after ischemia-reperfusion injury. (A) qPCR showing pre-miR-21 treatment up-regulated miR-21 level, whereas antagomiR-21 down-regulated the expression of miR-21. (B) The expression of AR mRNA in the renal tissue by qPCR. (C) PDCD4 mRNA level was negatively correlated with the expression of miR-21 in mice with ischemia-reperfusion injury. (D) pre-miR-21 induced the expression of cleaved caspase-3 and PDCD4 protein after renal ischemia-reperfusion, yet antagomiR-21 reduced. (E) Quantitative evaluation of PDCD4 protein levels in renal tissue. (F) Quantitative evaluation of cleaved caspase-3 protein levels in renal tissue. Data displayed are mean ± SEM (n > 5). Compared with sham operation group, *p < 0.05. Compared with Control + IR group, #p < 0.05.