TABLE 1.
Theories proposed for the etiology of endometriosis.
Theory | Mechanism proposed |
Retrograde menstruation theory | Retrograde menstruation permits implantation of endometrial glands and stroma into the peritoneal cavity (13) |
Coelomic metaplasia theory | Endometriosis can develop in all celomic wall derivatives because of a metaplastic phenomenon (27) |
Hematogenous/lymphatic spread theory | Dissemination of endometrial cells takes place by lymphatic or hematogenous vessels (35) |
Stem cell recruitment theory | Endometrial and/or hematopoietic stem cells could differentiate into endometriotic tissue at different anatomical sites (37) |
Embryogenetic theory | Persistence of residual embryonic cells of Wolffian or Müllerian ducts may develop into endometriotic lesions in response to estrogen (17) |
The most relevant references are indicated.