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FAK PROTAC inhibits both FAK activity and degrades FAK protein. (A) FAK PROTAC binds FAK kinase inhibitor VS6063 and ubiquitin ligase E3. (B) WB analysis of FAK protein in both OVCAR3 and OVCAR8 cells following 24 h treatment at different doses. (C) WB analysis of FAK following 1 µM FAK PROTAC treatment at different time points. (D) WB analysis of FAK and pFAK in both OVCAR3 and OVCAR8 cells following 24 h treatment with 1 µM FAK PROTAC and VS6063. (*p<0.05; **p<0.01; ***p<0.001).
