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. 2022 Apr 28;12:851065. doi: 10.3389/fonc.2022.851065

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Copyright © 2022 Huo, Zhang, Zhao, Chen, Dong, Watari, Narayanan, Tillmanns, Pfeffer and Yue

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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FAK PROTAC is more effective in inhibiting OC cell migration and invasion. (A–C) Cell migration in both OVCAR3 and OVCAR8 was examined using transwell plates (A) and wound healing assays (B, C). Migrated cells in transwells were stained with crystal violet and counted from three different fields under microscopy. Migration in wound healing assay was calculated by comparing migrated distance at 48h to 0h. (D). Invasion in OVCAR3 and OVCAR8 was examined using Matrigel coated transwell plates following 4h treatment with 1µM PROTAC or VS6063 and compared to vehicle treated cells. (*p<0.05; **p<0.01; ***p<0.001; ns, not significant).