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. 2022 Apr 28;12:851065. doi: 10.3389/fonc.2022.851065

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Copyright © 2022 Huo, Zhang, Zhao, Chen, Dong, Watari, Narayanan, Tillmanns, Pfeffer and Yue

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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FAK PROTAC disrupts the interaction between FAK and ASAP1 in OC cells. (A) OVCAR3 cells were treated with 1 µM FAK PROTAC and VS6063 for 24 h, WB of input shows changes in pFAK, FAK, and ASAP1 in each group. (B) Protein complex was pulled down with ASAP1 antibody and then blotted with both FAK and ASAP1 antibody. (*p<0.05; **p<0.01; ***p<0.001).