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. 2022 Apr 28;12:851065. doi: 10.3389/fonc.2022.851065

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Copyright © 2022 Huo, Zhang, Zhao, Chen, Dong, Watari, Narayanan, Tillmanns, Pfeffer and Yue

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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FAK PROTAC inhibits OC growth and metastasis. (A, B) Ovarian tumor growth and metastasis were shown by bioluminescence following three-week treatment with vehicle and FAK PROTAC in live animals (A) and ovarian tumors were also imaged (B) and weighted (C) in vehicle and FAK PRTOAC treated mice. (D) H.E and immunohistochemical staining against FAK and Ki67 of ovarian tumor sections in FAK PROTAC and vehicle treated mice. (E) WB analysis of FAK protein in ovarian tumors of FAK PROTAC and vehicle treated mice. (***p<0.001).