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. 2022 Apr 28;13:874637. doi: 10.3389/fphar.2022.874637

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Copyright © 2022 Wang, Gao, Wang, Ma, Zhang, Xing, Jia and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Identification of core targets of VD3 against STAD and COVID-19. (A) STRING analysis of VD3 and STAD/COVID-19 intersecting genes. (B) Cytoscape analysis representing the gene interaction networks associated with VD3 anti-STAD/COVID-19. The top five hub genes—CXCL8, CSF2, ALB, SERPINE1 and IL1A—are highlighted. (C) Diagram of receptor and ligand (VD3 or calcitriol).