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Main functions of circRNAs. (A) CircRNAs can adsorb miRNAs to activate signaling pathways. (B) EIciRNA and U1 snRNP form a complex that interacts with the RNA Pol II complex to regulate gene transcription. (C) Circ-ANRIL binds to PES1 protein to increase the number of cell nucleoli and pre-rRNA accumulation, thereby promoting apoptosis. (D) CircRNAs can be translated into protein through an IRES.
