Table 3.
The cutoff values of D-dimer, PAI-1, TAT, and F1 + 2 levels.
| Variable | AUC | Cutoff value | Se, % | Sp, % | J | PPV, % (95% CI) |
NPV, % (95% CI) |
LR + (95% CI) | LR– (95% CI) |
|---|---|---|---|---|---|---|---|---|---|
| D-dimer (ug/mL, T4) | - | 0.5 | 100 | 0.5 | 0.005 | 25.00 (20.06-30.69) |
- | 1.0 (1.0 - 1.0) |
0.5 |
| D-dimer (ug/mL, T4) | 0.645 | 2.24 | 65.08 | 64.02 | 0.291 | 37.61 (28.66 - 47.44) |
84.62 (77.42 - 89.91) |
1.81 (1.4 - 2.4) | 0.55 (0.4 - 0.8) |
| PAI-1 (ng/mL, T3) | 0.773 | 35.96 | 52.38 | 88.89 | 0.413 | 61.11 (46.87 - 73.77) |
84.85 (78.92 - 89.39) |
4.71 (3.0 - 7.5) | 0.54 (0.4 - 0.7) |
| TAT (ng/mL, T3) | 0.771 | 13.36 | 96.83 | 58.20 | 0.550 | 43.57 (35.30 - 55.20) |
98.21 (93.06 - 99.69) |
2.32 (1.9 - 2.8) | 0.055 (0.01 - 0.2) |
| F1 + 2 (ng/mL, T3) | 0.797 | 11.1 | 74.60 | 78.31 | 0.529 | 53.41 (42.51 - 64.01) |
90.24 (84.28 - 94.14) |
3.44 (2.5 - 4.7) | 0.32 (0.2 - 0.5) |
PAI-1, plasminogen activator inhibitor-1; TAT, thrombin–antithrombin; F1 + 2, prothrombin fragment F1 + 2; T3, postoperative day 1; T4, postoperative day 3; AUC, area under the curve; Se, sensitivity; Sp, specificity; J, Youden index; PPV, positive predictive value; NPV, negative predictive value; LR + , positive likelihood ratio; LR–, negative likelihood ratio; 95% CI, 95% confidence interval.