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. 2022 Apr 28;10:895159. doi: 10.3389/fchem.2022.895159

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Copyright © 2022 Wang, Sun, Xie, Long, Chen, He, Zou, Mao and Xia.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) FE-SEM and AFM analysis of the morphology of P. aeruginosa after incubation with Au1 or auranofin. (B) Quantification of the root-mean-square roughness (R_q) of the bacterial surface. All experiments are performed in triplicated and data are presented as mean ± sd. *** means p < 0.001. (C) Flow cytometry analysis of the bacterial membrane permeability after incubation with auranofin, Au1 and polymyxin B. Blue colour represents the counted cell with impermeable membrane, and red colour represents the cell with permeable membrane.