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. 2022 Apr 28;10:895159. doi: 10.3389/fchem.2022.895159

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Copyright © 2022 Wang, Sun, Xie, Long, Chen, He, Zou, Mao and Xia.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Schematic illustration of the mice infection experiment. (B) The representative images and curves (C) of wound areas of control, aranofin-, and Au1-treated groups. Scale bar: 5 mm. (D) Mice weight changes within 8 days in various experimental groups. (E) The representative images and quantification of P. aeruginosa bacteria in the mice wounds. All experiments are performed in triplicated and data are presented as mean ± sd. * means p < 0.05, ****means p < 0.0001. (F) Gram, H&E and Masson’s trichrome staining of mice wound tissues in various experimental groups. Scale bar: 500 μm.