Table 3.

Results of meta-regression analysis: we performed random-effects meta-regression to assess the impact of study characteristics and potential confounders on the effect sizes of OCTA measurements, using SMD as the outcome variable.

	Mean MMSE score differences		Age differences		Gender ratio differences		OCTA models (RTVue vs. Cirrus 5000)		Macular scan size (3x3 vs. 6x6)
	β coefficient	p -value	β coefficient	p -value	β coefficient	p -value	β coefficient	p -value	β coefficient	p -value
FAZ (AD vs. Controls)
Mean	−0.186	0.157	−0.168	0.047	1.157	0.545	0.923	0.008	0.673	0.139
FAZ (MCI vs. Controls)
Mean	0.089	0.385	−0.056	0.554	−1.867	0.254	0.165	0.620	0.543	0.030
SCP vessel density (AD vs. Controls)
Mean	0.093	0.129	0.032	0.635	−0.457	0.658	−0.069	0.774	0.422	0.008
SCP vessel density (MCI vs. Controls)
Mean	−0.189	0.124	0.077	0.451	−0.730	0.750	−0.446	0.257	−0.078	0.860
DCP vessel density (AD vs. Controls)
Mean	0.526	0.265	−0.026	0.937	−1.070	0.774	−0.336	0.730	−1.438	0.031
DCP vessel density (MCI vs. Controls)
Mean	0.028	0.817	0.121	0.050	1.583	0.439	−0.419	0.152	−0.326	0.325

p-values marked in bold indicate significance on the 95% confidence limit.

AD, Alzheimer's Disease; MCI, Mild cognitive impairment; OCTA, Optical coherence tomography angiography; MMSE, Mini–Mental State Examination; SCP, Superficial capillary plexus; DCP, Deep capillary plexus; FAZ, Foveal avascular zone.