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. 2022 Apr 28;14:860759. doi: 10.3389/fnagi.2022.860759

Table 4.

Summary of differences of OCTA measurements and risk of publication bias using Egger's test.

Overall effect Heterogeneity Egger's test Overall effect Heterogeneity Egger's test Overall effect Heterogeneity Egger's test
SMD p -value I 2 Q (P) SMD p -value I 2 Q (P) SMD p -value I 2 Q (P)
AD vs. Controls MCI vs. Controls AD vs. MCI
FAZ 0.54 [0.09, 0.99] 0.02 84.1% <0.001 0.0002 0.27 [−0.03, 0.57] 0.08 58.2% 0.04 0.848 −0.07 [−0.32, 0.18] 0.59 0.0% 0.69 0.651
Choroidal thickness −0.58 [−1.26, 0.10] 0.09 88.4% <0.001 0.436 - - - - - - - - - -
SCP vessel density
   Mean −0.48 [−0.70, −0.27] <0.001 48.2% 0.04 0.227 −0.42 [−0.81, −0.03] 0.03 79.3% <0.001 0.705 −0.29 [−0.64, 0.07] 0.12 59.3% 0.04 0.145
   Fovea −0.38 [−0.66, −0.10] 0.01 36.6% 0.19 0.025 −0.36 [−0.65, −0.07] 0.02 20.7% 0.26 0.573 0.04 [−0.61, 0.68] 0.91 75.5% 0.04 -
   Parafovea −0.48 [−0.71, −0.25] <0.001 41.6% 0.10 0.217 −0.37 [−0.95, 0.21] 0.21 83.1% <0.001 0.528 −0.31 [−0.82, 0.20] 0.23 74.4% 0.01 0.119
DCP vessel density −1.19 [−2.00, −0.38] <0.001 92.4% <0.001 0.002 −0.53 [−0.85, −0.22] <0.001 59.7% 0.02 0.968 −0.68 [−1.37, 0.01] 0.05 84.1% <0.001 0.206
Peripapillary vessel density −0.17 [−0.66, 0.31] 0.49 70.5% 0.04 0.221 −0.43 [−0.73, −0.14] <0.001 0.0% 0.53 0.268 - - - - -
Choroidal perfusion density −0.01 [−0.22, 0.20] 0.91 0.0% 0.73 0.719 −0.27 [−0.80, 0.26] 0.31 61.3% 0.11 0.24 [−0.29, 0.77] 0.37 48.2% 0.16

SCP, Superficial capillary plexus; DCP, Deep capillary plexus; FAZ, Foveal avascular zone.