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. 2022 Apr 28;14:856628. doi: 10.3389/fnagi.2022.856628

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Copyright © 2022 Liu, Jiao, Zhong, Yao, Du, Lu, Wu, Ma, Tong, Xu, Jiang, Wang, He, Xin and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Enrichment and protein-protein interaction (PPI) network analysis of differentially expressed genes (DEGs) in the hippocampus of Alzheimer’s Disease (AD) patients from GSE1297. (A) The top-10 statistically significant biological processes related to the 32 DEGs based on KEGG pathway enrichment and GO functional annotation analyses. (B) Protein-protein interactions between the pathogenic gene, APP, and the 32 DEGs using the bisoGenet plug-in of the Cytoscape3.6.1 software.