Table 4.
Functionalized citrate-based polymers for skin tissue engineering.
| Materials | Component | Properties | Tissue engineering | Ref. |
|---|---|---|---|---|
| POC/PAA | POC; PAA | Mimicked dermis structure; Antibacterial activity; Enhance fibroblasts adhesion and proliferation | Bacterial infection wound healing | 173 |
| PCE/PCL | POC; EPL; PCL | Good tensile elastomeric; Hydrophilicity; Antibacterial ability; Promote collagen deposition and angiogenesis | Bacterial infection wound healing | 174 |
| PPCP | PCS; PLLA; Curcumin; Polydopamine | Antioxidant, Anti-inflammatory; Broad-spectrum antibacterial | Cutaneous tumor therapy and inflection-induced wound healing | 175 |
| POC-C/POC-T/POC-H/POC-M | POC; Quaternary ammonium; Phosphonium | Good antibacterial efficacy; appropriate mechanical properties | Antimicrobial wound dressings | 176 |
| CG-POCG | POC; PEG; chitosan; β-glycerophosphate | Downregulate the pro-inflammatory cytokines; Upregulate angiogenic factors | Accelerate skin wound repair | 177 |
| FEA-PCEI | POC; PEG; PEI; Ibuprofen; F127; EPL; Sodium alginate | Injectable; Antibacterial; Increase anti-inflammatory M2 macrophage; Inhibiting inflammatory factors expression; | Accelerate wound healing and hair follicle neogenesis | 178 |
| FEPCGS | POC; PEG; Siloxane; F127; EPL | Injectable; antibacterial; anti-inflammatory; Promote fibroblasts proliferation and endothelial cells migration | MDRB-infected wound healing | 179 |
| iCMBA | Citric acid; PEG; Dopamin | High adhesion strength; Controllable mechanical properties and degradation properties | Hemostatic adhesive and wound closure | 180,181 |
| iCMBA-EPE/MgO | Citric acid; PEG-PPG-PEG diol; Magnesium oxide | High adhesive strength; Low swelling ratio; Good antibacterial and hemostatic ability | Promote wound closure and potential bone regeneration | 182 |
| AbAf iCs | iCMBA; 10-undecylenic acid | Strong wet tissue adhesion; Long-term antibacterial and antifungal abilities | Bacterial or fungal infections tissue engineering | 183 |
| POC/PLA | POC; PLA | Elastic; Hydrophilic; Sustained release aspirin | Wound dressing | 184 |
| H-HKUST-1 | PPCN; HKUST-1 NPs | Sustained release of copper ions; Antioxidant property; Promotion of collagen deposition and angiogenesis | Accelerate diabetic wound healing | 185 |
POC: poly(octamethylene citrate); PAA: poly (acrylic acid); PLA: polylactic acid; EPL: ε-polylysine; PCL: poly caprolactone; PCS: 3-aminopropyltriethoxysilane grafted POC; PLLA: poly (l-lactic acid); PEG: polyethylene glycol; PEI: polyethyleneimine; F127: Pluronic F-127; MDRB: multidrug resistant-bacteria; PEG-PPG-PEG diol: poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol); PPCN: thermoresponsive POC-based polymer comprised of citric acid, polyethylene glycol and poly-N-isopropylacrylamide; HKUST-1 NPs: copper metal-organic framework nanoparticles.