Table 5. Factors associated with the false-negative QFT-GIT assay results in patients with pleural TB.
| Factor | Univariate analysis | Multivariate analysis | |||||
|---|---|---|---|---|---|---|---|
| Crude OR | 95% CI | P value | Adjusted OR | 95% CI | P value | ||
| Age | 1.02 | 1.00–1.03 | 0.061 | ||||
| ESRD | 3.42 | 1.08–10.22 | 0.029 | 3.99 | 1.01–14.70 | 0.039 | |
| Haematological malignancy | 2.62 | 0.98–6.59 | 0.044 | ||||
| Pneumoconiosis | 4.97 | 1.12–22.02 | 0.029 | 8.96 | 1.48–49.56 | 0.012 | |
| Discontinuation of anti-TB medication | 2.55 | 0.15–0.69 | 0.027 | ||||
| Death | 4.46 | 1.35–14.35 | 0.011 | ||||
| Not TB-related death | 6.41 | 1.61–27.2 | 0.008 | ||||
| Serum lymphocyte (%) | 1.01 | 0.98–1.06 | 0.446 | ||||
| Serum protein | 2.17 | 1.35–3.62 | 0.002 | ||||
| Serum albumin | 1.88 | 0.95–3.77 | 0.072 | ||||
| Hypoproteinaemia† | 4.83 | 2.15–10.86 | <0.001 | 7.12 | 2.82–18.78 | <0.001 | |
| Pleural fluid pH‡ | 2.44 | 0.44–13.42 | 0.303 | ||||
| Pleural fluid protein | 1.22 | 0.88–1.69 | 0.216 | ||||
| Pleural fluid albumin | 2.33 | 1.16–4.72 | 0.018 | ||||
| Pleural ADA <70 | 2.69 | 1.20–5.92 | 0.015 | ||||
| Pleural fluid pH >7.6 | 3.03 | 1.18–7.45 | 0.017 | 5.25 | 1.75–15.68 | 0.003 | |
†, hypoproteinaemia was defined as serum protein <6.0 g/dL; ‡, per 1 unit decrease. QFT-GIT, QuantiFERON-TB Gold In-Tube; TB, tuberculosis; OR, odds ratio; CI, confidence interval; ESRD, end-stage renal disease; ADA, adenosine deaminase.