Figure 9.

Overview of the main findings of the present study. The blue rectangles indicate the situations in which there is a response to increase brain energy availability. Alternatively, the pink rectangles are indicative of responses triggering increased energy expenditure. Blue and pink stars show improvement and worsening of migraine-like changes, respectively. The blue and pink spiked circles show improvement and worsening of affective-behavior changes, correspondingly. The question marks represent the issues that need further investigation. Figure created with BioRender.com. CGRP, calcitonin gene-related peptide; e-NOS, endothelial nitric oxide synthase; IL-6, interleukin-6; HFD, high-fructose diet; NTG, nitroglycerin; TNF-α, tumor necrosis factor-α; TRPV-1, transient receptor potential vanilloid 1.