Table 1. GO analysis of DEGs in melanoma tissues.

Expression	Category	Term	Count	%	P value	FDR
Upregulated	GOTERM_BP_DIRECT	GO:0043542~endothelial cell migration	4	2.649006623	0.001429913	1
	GOTERM_BP_DIRECT	GO:0001938~positive regulation of endothelial cell proliferation	5	3.311258278	0.002010012	1
	GOTERM_BP_DIRECT	GO:0010628~positive regulation of gene expression	8	5.298013245	0.004314346	1
	GOTERM_BP_DIRECT	GO:0006631~fatty acid metabolic process	4	2.649006623	0.007600221	1
	GOTERM_BP_DIRECT	GO:0071333~cellular response to glucose stimulus	4	2.649006623	0.007600221	1
	GOTERM_BP_DIRECT	GO:0007165~signal transduction	18	11.9205298	0.008212234	1
	GOTERM_CC_DIRECT	GO:0070062~extracellular exosome	41	27.15231788	5.21E-05	0.009220898
	GOTERM_CC_DIRECT	GO:0005615~extracellular space	24	15.89403974	2.38E-04	0.016008507
	GOTERM_CC_DIRECT	GO:0005765~lysosomal membrane	10	6.622516556	2.71E-04	0.016008507
	GOTERM_CC_DIRECT	GO:0042470~melanosome	6	3.973509934	0.001092801	0.048356431
	GOTERM_CC_DIRECT	GO:0005789~endoplasmic reticulum membrane	16	10.59602649	0.002606126	0.092256876
	GOTERM_CC_DIRECT	GO:0043202~lysosomal lumen	5	3.311258278	0.004176494	0.123206574
	GOTERM_MF_DIRECT	GO:0016491~oxidoreductase activity	7	4.635761589	0.004053253	1
	GOTERM_MF_DIRECT	GO:0042605~peptide antigen binding	3	1.986754967	0.018681714	1
	GOTERM_MF_DIRECT	GO:0015184~L-cystine transmembrane transporter activity	2	1.324503311	0.029757723	1
	GOTERM_MF_DIRECT	GO:0008083~growth factor activity	5	3.311258278	0.034060443	1
	GOTERM_MF_DIRECT	GO:0005125~cytokine activity	5	3.311258278	0.043985806	1
Downregulated	None

GO, Gene Ontology; DEG, differentially expressed gene; FDR, false discovery rate.