Table 2. Cost and health resource utilization.

Medical expense	Items	Cost (USD)	Notes
Drug cost (cost per cycle)	PPI group (standard dose, QD)	65	Unit cost ×28 days*
	VPZ 20 mg QD	40
	PPI group (low dose, QD)	34
	VPZ 10 mg QD	20
Outpatient visit	Visit during healing phase	15	Twice a month
	Visit during maintenance phase	7	Once a month
Endoscopy	For diagnosis	84	Once
24-hour pH monitoring	For patients who were unhealed after 8-week treatment	116	Once

*, cycle costs for PPI group and VPZ can be calculated by multiplying the unit cost by 28 days. PPI, proton pump inhibitors; QD, once daily; VPZ, vonoprazan.