Table 3. Univariate and multivariate Cox regression analysis of the effects of CRNDE and clinical factors on the prognosis of THCA patients.
| Variables | Univariate analysis | Multivariate analysis | |||||
|---|---|---|---|---|---|---|---|
| HR | 95% CI | P value | HR | 95% CI | P value | ||
| CRNDE expression | 2.12 | 1.33–3.40 | 1.70E-03 | 2.08 | 1.17–3.72 | 1.31E-02 | |
| Tumor stage (stage III_IV vs. I_II) | 7.14 | 2.3–22.19 | 6.82E-04 | 0.52 | 0.09–3.03 | 4.68E-01 | |
| T stage (T3_T4 vs. T1_T2) | 3.11 | 1.08–8.96 | 3.56E-02 | 0.54 | 0.10–2.86 | 4.71E-01 | |
| N stage (N1 vs. N0) | 1.47 | 0.48–4.51 | 4.97E-01 | – | – | – | |
| M stage (M1 vs. M0) | 4.74 | 1.01–22.22 | 4.84E-02 | – | – | – | |
| Residual tumor (R1_R2 vs. R0) | 3.69 | 1.11–12.25 | 3.32E-02 | 11.55 | 2.14–62.44 | 4.50E-03 | |
| Gender (male vs. female) | 1.93 | 0.7–5.34 | 2.05E-01 | – | – | – | |
| Race (white vs. others) | 1.41 | 0.32–6.22 | 6.48E-01 | – | – | – | |
| Age | 1.16 | 1.10–1.22 | 2.08E-08 | 1.19 | 1.10–1.28 | 3.52E-06 | |
| Disease history (yes vs. no) | 0.16 | 0.02–1.23 | 7.89E-02 | – | – | – | |
| Location (isthmus vs. bilateral) | 1.11 | 0.1–12.47 | 9.31E-01 | – | – | – | |
| Location (left lobe vs. bilateral) | 0.95 | 0.19–4.81 | 9.52E-01 | – | – | – | |
| Location (right lobe vs. bilateral) | 0.90 | 0.18–4.53 | 9.02E-01 | – | – | – | |
CRNDE, colorectal neoplasia differentially expressed; THCA, thyroid cancer; HR, hazard rate; CI, confidence interval.