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. 2022 May 4;2022:8169981. doi: 10.1155/2022/8169981

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Copyright © 2022 Kexin Kang et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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PPI network and AUC analysis. (a) Scatterplots of the relationship between MM (x-axis) and GS (y-axis). (b) PPI network based on turquoise module genes: node size reflects the degree of gene connectivity; down-regulated IGF1 is marked in yellow; blue and red represent down-regulated and up-regulated, respectively. (c) Cross-talking pathways of IGF1: down-regulated IGF1 is marked in yellow. (d) The predictive performance of IGF1 in AD measured by AUC analysis. (e) IGF1 expression between AD and non-dementia controls in training sets. AD: Alzheimer's disease: AUC: area under the curve; GS: gene significance; MM: module membership; PPI: protein-protein interaction.