Table 3. Clinical Outcomes of PIMSRA at Last Follow-up.
| Variable | No. (%) | P value | |
|---|---|---|---|
| Baseline (n = 200) | At last follow-up (n = 198)a | ||
| Clinical results | |||
| NYHA functional classification | |||
| I | 0 | 167 (84.3) | <.001 |
| II | 58 (29.0) | 23 (11.6) | |
| III | 126 (63.0) | 8 (4.0) | |
| IV | 16 (8.0) | 0 | |
| 6-min Walk distance, mean (SD) | 422.3 (89.0) | 451.1 (81.9) | <.001 |
| Echocardiographic results | |||
| Maximum septal thickness, mean (SD), mm | 24.0 (5.1) | 17.3 (4.4) | <.001 |
| LVOT diameter, median (IQR), mm | 6.0 (3.0) | 11.0 (5.9) | <.001 |
| Mitral valve SAM grade | |||
| 0 | 18 (9.0) | 115 (58.1) | <.001 |
| 1 | 11 (5.5) | 34 (17.2) | |
| 2 | 65 (32.5) | 43 (21.7) | |
| 3 | 106 (53.0) | 6 (3.0) | |
| LVOT peak gradient, median (IQR), mm Hg | |||
| Resting | 79.0 (53.0) | 14.0 (24.0) | <.001 |
| Provoked | 127.0 (65.5) | 47.0 (76.5) | <.001 |
| Left atrial volume index, mean (SD), mL/m2 | 49.5 (15.0) | 35.9 (11.7) | <.001 |
| LVEDV, mean (SD), mL | 76.4 (17.1) | 78.0 (16.3) | .20 |
| LVESV, mean (SD), mL | 30.9 (8.5) | 31.9 (8.6) | .11 |
| LVEF, mean (SD), % | 60.2 (4.7) | 59.2 (3.8) | .008 |
| Exercise time, median (IQR), s | 360 (120) | 540 (225) | <.001 |
| Electrocardiographic results | |||
| Left bundle branch block | 1 (0.5) | 1 (0.5) | >.99 |
| Right bundle branch block | 10 (5.0) | 15 (7.6) | .06 |
| Atrioventricular block (all types) | 5 (2.5) | 5 (2.5) | >.99 |
| Nonsustained VT | 12 (6) | 16 (8.1) | .45 |
| Ventricular premature beat, median (IQR) | 11.0 (43.0) | 8.5 (43.5) | .82 |
Abbreviations: LVEDV, left ventricular end diastolic volume; LVEF, left ventricular ejection fraction; LVESV, left ventricular end systolic volume; LVOT, left ventricular outflow tract; NYHA, New York Heart Association; PIMSRA, percutaneous intramyocardial septal radiofrequency ablation; SAM, systolic anterior motion; VT, ventricular tachycardia.
a
Median (IQR) follow-up of 19.0 (6-50) months.