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. 2022 May 11;5(5):e2211616. doi: 10.1001/jamanetworkopen.2022.11616

Table 2. Bayesian Alternative Design Interim Analyses.

No. of patients enrolled No. of patients with 90-d outcome Good outcome proportion, % Predictive probability of trial success, %
Treatment Control Current sample size success stopping bound >99% Maximum sample size futility stopping bound <5%
498 432 26.6 24.6 <1 21.1
579 515 25.7 22.3 <1 39.7
700 621 25.1 23.4 <1 15.6
800 715 23.1 22.80 <1 2.0