Table 2. Bayesian Alternative Design Interim Analyses.
No. of patients enrolled | No. of patients with 90-d outcome | Good outcome proportion, % | Predictive probability of trial success, % | ||
---|---|---|---|---|---|
Treatment | Control | Current sample size success stopping bound >99% | Maximum sample size futility stopping bound <5% | ||
498 | 432 | 26.6 | 24.6 | <1 | 21.1 |
579 | 515 | 25.7 | 22.3 | <1 | 39.7 |
700 | 621 | 25.1 | 23.4 | <1 | 15.6 |
800 | 715 | 23.1 | 22.80 | <1 | 2.0 |