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. 2022 Apr 28;14:866313. doi: 10.3389/fnagi.2022.866313

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Copyright © 2022 Bonney, Briggs, Wu, Choi, Khahera, Ojogho, Shao, Zhao, Borzage, Wang, Liu and Lee.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The blood-brain barrier consists of endothelial tight junctions, pericytes, and astrocytic endfeet. A leaky blood-brain barrier through dysfunction of one or multiple of these constituent parts has been demonstrated in iNPH.