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. 2022 May 4;53:102324. doi: 10.1016/j.redox.2022.102324

Fig. 3.

Fig. 3

WJ460 induces lipid peroxidation in PDAC cell lines.

(A–B) Malondialdehyde (MDA) concentration in PDAC (BxPC-3, MiaPaCa-2, Panc-1, PaTu 8988T) and pancreas normal epithelial (HPNE) cell lines exposed to 50 nM WJ460 for 24 h. Each data point represents mean ± SEM, n = 4. ***P < 0.001, **P < 0.01, *P < 0.05. (C) Trolox 5 mM mitigates the WJ460-induced reduction of cell confluency. Each data point represents mean ± SEM, n = 3. (D) Western-blot showing the xc- transporter SLC7A11, and glutathione peroxidase (GPX)-4 in PaTu 8988T and HPNE cells exposed to 50 nM WJ460 for 8–24 h. HSC70 was used as a loading control. Associated charts represent the relative abundance of SLC7A11 and GPX-4.