Skip to main content
. 2022 Apr 28;7(18):15296–15307. doi: 10.1021/acsomega.2c00581

Figure 2.

Figure 2

(A) Basic experimental design for nucleic acid sensing. (B) Different strategies for immobilization of ssDNA/ssXNA on surface via (I) gold–thiol linkage formation, (II) NHS-EDC activated immobilization, (III) affinity binding of avidin and biotinylated nucleic acid strand, (IV) dithiol linkage formation on 3-MPTMS-modified silicon surface, and (V) formation of secondary imine using glutaraldehyde cross-linker on 3-APTES-modified silicon surface.