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. 2022 Apr 28;10:847157. doi: 10.3389/fcell.2022.847157

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Copyright © 2022 van Dieken, Staecker, Schmitt, Harre, Pich, Roßberg, Lenarz, Durisin and Warnecke.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Druggability status of the 203 tissue-specific proteins. Based on Pharos, targets are divided into four categories. Of all tissue specific proteins, 5% were identified as targets for clinically approved drugs. For 15% of the proteins, active ligands (Tchem) were identified. Seventy six percent of perilymph proteins have an identifiable gene ontology and can be functionally classified but do not have available inhibitors (Tbio). Finally, a small percentage of identified proteins are unclassified (Tdark).