FIGURE 5.

Effect of local carbon dioxide application on microvascular perfusion variables: Perfused vessel density (PVD) in (mm/mm²) (A) and Microvascular flow index (MFI) (B) at oral mucosa under hemorrhagic conditions. The animals received a continuous gas application with either N₂ to maintain local normocapnia (NC-H) or CO₂ for local hypercapnia (HC-H) followed by hemorrhage and retransfusion. One hour of acute hemorrhage is marked gray. Data are presented as mean SEM for n = 6 dogs; *p < 0.05 vs. control group (NC-H), 2-way ANOVA for repeated measurements followed by the Bonferroni post-hoc test.