FIGURE 3.

Structure of the common TUBB3 mRNA transcripts. Structure of the two common TUBB3 transcripts showing the validated binding sites of the HuR protein and the miR-200 family. Transcripts are represented by a combination of thin and thick boxes for exons, and arrows for introns; thin boxes represent untranslated regions (5′ and 3’ UTRs), while thick boxes represent translated regions. TUBB3 transcript variants 1 and 2 are show in red and blue respectively and have been aligned to show common regions. RNA binding sites represented by boxes under their approximate location, with thickness corresponding to size. HuR binding site validated by (Prislei et al., 2013); miR-200c binding confirmed by (Cochrane et al., 2009); miR-200b binding confirmed by (Wu et al., 2020); miR-429 binding predicted by (Susanna et al., 2011); miR-200c binding confirmed by (Cochrane et al., 2009); miR-200b binding confirmed by (Wu et al., 2020); miR-429 binding predicted by (Susanna et al., 2011).