TABLE 3.

Transcription factors and Genomic elements associated with Tubb3 expression in Mice and Rats.

Element type	Species Identified in	Role	Binding site validated	References
Transcription factors
Sp1	Rat	Promotes expression	in silico only	(Dennis et al., 2002; Sleiman et al., 2011)
Ap2	Rat	Unknown	in silico only	Dennis et al. (2002)
Pea3 a	Rat	Unknown	in silico only	Dennis et al. (2002)
Pit1 a	Rat	Unknown	in silico only	Dennis et al. (2002)
C/EBP family	Rat	Unknown	in silico only	Dennis et al. (2002)
Rest1	Rat & Mouse	Inhibits expression	in silico only	(Dennis et al., 2002; Shibazaki et al., 2012)
Scrt1	Mouse	Promotes expression	No, potentially E-Box motifs	Nakakura et al. (2001b)
Math2	Mouse	Promotes expression	No, potentially E-Box motifs	Uittenbogaard and Chiaramello (2002)
pRB	Mouse	Promotes expression	No, potentially E-Box motifs	Toma et al. (2000)
Id2	Mouse	Inhibits expression	N/A, impairs other transcription factors binding	Le Dréau et al. (2018)
Pax3	Rat & Mouse	Inhibits expression	Yes (Rat)	(Cao et al., 2017; Wei et al., 2018)
SoxC family (Sox4, Sox11, Sox12)	Mouse	Promotes expression	Yes	(Bergsland et al., 2006; Hoser et al., 2008)
Binding elements
E-box motifs	Rat	Unknown	in silico only	Dennis et al. (2002)
Central nervous system enhancer motifs	Rat	Unknown	in silico only	Dennis et al. (2002)
Tata box	Rat	Unknown	in silico only	Dennis et al. (2002)
Androgen response elements	Mouse & Rat	Promotes expression	Yes (Mice)	De Gendt et al. (2011)

^aPit1 and Pea3 sites not observed in mice (Liu et al., 2007).