TABLE 4.

Transcription factors with known impact on TUBB3 expression.

Transcription factor	Species	Role	References
Androgen receptor	Mouse, Human	Promotes	(Denolet et al., 2006; De Gendt et al., 2011) Butler et al. (2001)
Estrogen receptor	Human	Promotes	Saussede-Aim et al. (2009a)
HIF1α	Human	Promotes Inhibits	Raspaglio et al. (2014), Bordji et al. (2014)
HIF2a	Human	Promotes	Raspaglio et al. (2008)
ID2	Human, Mouse	Inhibits	(Le Dréau et al., 2018), Azzarelli et al. (2022)
Math2	Mouse	Promotes	Uittenbogaard and Chiaramello (2002)
MZF1	Human	Promotes	Kanojia et al. (2020)
Pax3	Rat, Mouse	Inhibits	Cao et al. (2017), Wei et al. (2018)
RARa	Human	Promotes	Namekawa et al. (2020)
RE1	Human	Inhibits	Shibazaki et al. (2012)
Scrt1	Mouse	Promotes	Nakakura et al. (2001b)
SOXC family (4, 11, 12)	Mouse, Human a	Promotes	(Bergsland et al., 2006; Hoser et al., 2008) (Castillo et al., 2012; Fu et al., 2019)
SOX9	Human	Promotes	Raspaglio et al. (2014)
ZEB1	Human	Promotes b	(Lobert et al., 2013; Kanojia et al., 2020)
ZIC1	Human	Promotes	(Fu et al. 2019)

^aOnly SOX4 and SOX11 have been confirmed in humans.

^bZEB1 is only implied as binding site, while identified, was not reported.