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. 2022 Apr 25;7(18):15561–15569. doi: 10.1021/acsomega.2c00280

Figure 6.

Figure 6

Inhibition of the in vivo myotoxic activity of myotoxin II by different concentrations of JB006. An intramuscular injection (50 μL) containing 50 μg (3.6 nmol; 73 μM) of myotoxin II, previously incubated for 30 min at 37 °C with different concentrations of JB006 (900, 100, or 20 μM) or PBS as the negative control, was administered to groups of five mice. After 3 h, a blood sample was collected from the tail. Plasma was obtained following centrifugation and used to determine the activity of CK, an enzyme released due to muscle damage. Results are presented as mean ± SD (n = 5). Mice injected with myotoxin II incubated with 900 μM of JB006 showed a statistically significant difference [P < 0.01 (**)] when compared with mice injected with myotoxin II incubated with PBS.