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. 2022 May 12;20:102. doi: 10.1186/s12915-022-01288-1

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1. — Noise exposure did not induce hearing threshold shifts. A Experimental timeline highlighting the ABR recordings before and after noise exposure. B ABR representative example for 8–10-kHz frequency presented from 80 to 35dBSPL. Algorith-detected response peaks are marked with asterisks. Hearing threshold was defined at the last intensity with an identified peak, in this example, 50dBSPL. C Group hearing thresholds for each frequency tested before (blue) and after (orange) noise exposure (NE) for hM4Di (left) and eYFP (right) injected animals. D, E ABR Wave 1 (W.1) amplitudes at 80dBSPL (left) and growth functions (right) for the hM4Di (D) and eYFP (E) injected animals. Left, amplitude of wave 1 for each frequency tested 3d before (blue) and 3d after (orange) nose exposure. Right, wave 1 amplitude at each tested intensity, normalized by amplitude at 80dBSPL, at each tested frequency (cold blue-green colors: 3d before; warm red-yellow colors: 3d after noise exposure). n = 11 and 7 for NE hM4Di+ and NE eYFP, respectively