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. 2022 May 12;20:102. doi: 10.1186/s12915-022-01288-1

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4. — Inhibiting DCN CaMKII α-hM4Di-positive cell activity during noise exposure does not interfere with hearing at the tested frequencies. A Timeline of experiments highlighting ABR recordings before and after noise exposure. B, C Representative ABR traces (B) and group responses for hM4Di (C left) and eYFP (C right) injected mice that received i.p. CNO injection 30 min before noise exposure. D, E ABR Wave 1 (W.1) amplitudes at 80dBSPL (left) and growth functions (right) for the hM4Di (D) and eYFP (E) injected animals that received CNO before noise exposure. Left, amplitude of wave 1 for each frequency tested 3d before (blue) and 3d after (orange) noise exposure. Right, wave 1 amplitude at each tested intensity, normalized by amplitude at 80dBSPL, at each tested frequency (cold blue-green colors: 3d before; warm red-yellow colors: 3d after noise exposure). n = 6 and 6 for NE+CNO hM4Di+ and NE+CNO eYFP