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. 2022 May 12;20:102. doi: 10.1186/s12915-022-01288-1

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 7. — Three-dimensional scatter plots of firing rate, tuning width, and best frequency of DCN units of noise-exposed hM4Di+ or eYFP+ animals in the presence of NaCl or CNO. A, B 3D scatters representing each unit by firing rate x tuning width x best frequency for hM4Di (experimental; A and eYFP (control; B animals under NaCl (left) or CNO (right) treatment. C, D Same as A and B for experiments where animals were administered CNO (0.5mg/kg) 30 min prior to noise exposure. Colors represent the best frequency response between 8 and 16kHz. FR, firing rate; TW, tuning width; BF, best frequency; n = 11, 7, 6, and 6 mice; 122, 102, 85, and 91 units; for NE hM4Di+, NE eYFP, NE+CNO hM4Di+ and NE+CNO eYFP, respectively